What is the primary ion involved in GABAergic receptors?

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Study for the Neurophysiology Test with flashcards and multiple choice questions, each with hints and explanations. Enhance your understanding of cell types, signals, and sensory pathways. Ace your exam!

Multiple Choice

What is the primary ion involved in GABAergic receptors?

Explanation:
GABAergic inhibition is mainly carried by GABA_A receptors, which are ligand-gated chloride channels. When GABA binds, Cl− ions flow into the neuron, driven by the chloride gradient, hyperpolarizing the membrane and reducing excitability. This chloride conductance is the hallmark of the fast inhibitory effect. (GABA_B receptors are metabotropic and influence via potassium channels, but the primary ion associated with the classic GABAergic signal is chloride.)

GABAergic inhibition is mainly carried by GABA_A receptors, which are ligand-gated chloride channels. When GABA binds, Cl− ions flow into the neuron, driven by the chloride gradient, hyperpolarizing the membrane and reducing excitability. This chloride conductance is the hallmark of the fast inhibitory effect. (GABA_B receptors are metabotropic and influence via potassium channels, but the primary ion associated with the classic GABAergic signal is chloride.)

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